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Article

Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants.

Oncology research - 1 Jan 1994

Nguyen K T, Liu B, Ueda K, Gottesman M M, Pastan I, Chin K V

Abstract excerpt

Multidrug resistance in human cancer is associated with overexpression of the MDR1 gene, which encodes a plasma membrane energy-dependent efflux pump termed P-glycoprotein (or the multidrug transporter), which confers cross-resistance to multiple hydrophobic natural product cytotoxic drugs. We have previously shown in cotransfection experiments that activity of the human MDR1 gene promoter is modulated by Ras and...

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PMID: 7949467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants.PMID 7949467Read ↗

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