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Article

Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants.

Oncology research - 1 Jan 1994

Nguyen K T, Liu B, Ueda K, Gottesman M M, Pastan I, Chin K V

Abstract excerpt

Multidrug resistance in human cancer is associated with overexpression of the MDR1 gene, which encodes a plasma membrane energy-dependent efflux pump termed P-glycoprotein (or the multidrug transporter), which confers cross-resistance to multiple hydrophobic natural product cytotoxic drugs. We have previously shown in cotransfection experiments that activity of the human MDR1 gene promoter is modulated by Ras and...

Topics

Animals
Cells, Cultured
Chick Embryo
Drug Resistance, Multiple
Fibroblasts
Gene Expression Regulation, Neoplastic
Genes, p53
Genes, ras
Humans
Mutation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcriptional Activation

Transfection

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 7949467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7949467-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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