Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53.

Article

Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53.

Cancer research - 15 Dec 1998

Wang Q, Beck W T

Abstract excerpt

Multidrug resistance is a major obstacle to the success of cancer chemotherapy. The multidrug resistance-associated protein (MRP) has been shown to confer multidrug resistance. To study MRP gene expression at the transcriptional level, we have fused the MRP gene promoter with the luciferase repor...

Topics

Animals
Down-Regulation
Gene Expression Regulation, Neoplastic
Genes, MDR
Genes, p53
Humans
Mice
Mutation
Promoter Regions, Genetic
Sp1 Transcription Factor
Transcription, Genetic
Transfection
Tumor Cells, Cultured

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