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Article

p53-dependent regulation of <i>MDR1</i> gene expression causes selective resistance to chemotherapeutic agents

30 Sept 1997

Abstract excerpt

Loss of functional p53 paradoxically results in either increased or decreased resistance to chemotherapeutic drugs. The inconsistent relationship between p53 status and drug sensitivity may reflect p53's selective regulation of genes important to cytotoxic response of chemotherapeutic agents. We reasoned that the discrepant effects of p53 on chemotherapeutic cytotoxicity is due to p53-dependent regulation of the...

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Identifiers

PMID: 9380755
DOI: 10.1073/pnas.94.20.11037

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