Article
The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells.
Oncogene - 21 Jan 1999
Scotlandi K, Manara M C, Serra M, Benini S, Maurici D, Caputo A, De Giovanni C, Lollini P L, Nanni P, Picci P, Campanacci M, Baldini N
Abstract excerpt
The relationship between P-glycoprotein expression and malignancy is controversial. We have recently found that, in osteosarcoma, multidrug resistance (MDR) is associated with a less aggressive behavior, both in vitro and in clinical settings. In this study, we evaluated whether P-glycoprotein overexpression has a cause-effect relationship with the reduced metastatic potential of MDR cells, or rather reflects a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.