Article
Liver carcinogen aflatoxin B1 as an inducer of mitotic recombination in a human cell line.
Molecular carcinogenesis - 1 Jul 2001
Stettler P M, Sengstag C
Abstract excerpt
The mycotoxin aflatoxin B1 (AFB1) is one of the most potent rodent and human liver carcinogens. Upon cytochrome P450-specific metabolism, it induces mutations as well as mitotic recombination events in in vitro systems. We have found that in the lower eukaryote yeast, the recombinagenic activity of AFB1 surpasses its mutagenic activity, and we speculated on possible consequences in terms of the mechanism of liver...
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