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Article

A system for assaying homologous recombination at the endogenous human thymidine kinase gene.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1991

Benjamin M B, Potter H, Yandell D W, Little J B

Abstract excerpt

A system for assaying human interchromosomal recombination in vitro was developed, using a cell line containing two different mutant thymidine kinase genes (TK) on chromosomes 17. Heteroalleles were generated in the TK+/+ parent B-lymphoblast cell line WIL-2 by repeated exposure to the alkylating nitrogen mustard ICR-191, which preferentially causes +1 or -1 frameshifts. Resulting TK-/- mutants were selected in...

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Identifiers

PMID: 1677771
DOI: 10.1073/pnas.88.15.6652
PMCID: PMC52146

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