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Article

Assessment of the mutagenic, recombinogenic, and carcinogenic potential of amphotericin B in somatic cells of Drosophila melanogaster.

Drug and chemical toxicology - 1 Jan 2018

Saturnino Rosiane Soares, Machado Nayane Moreira, Lopes Jeyson Cesary, Nepomuceno Júlio César

Abstract excerpt

Amphotericin B (AmB) is an antifungal antibiotic extracted from Streptomyces nodosus. Its fungicidal activity depends primarily on its binding to the sterol group that is present in fungal membranes. In view of the toxicity of this drug, the purpose of this study was to evaluate its mutagenic, carcinogenic, and recombinogenic activity, based on the wing somatic mutation and recombination test (SMART) and the...

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Source

Identifiers

PMID: 28274136
DOI: 10.1080/01480545.2016.1188302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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