Article
Assessment of the mutagenic, recombinogenic, and carcinogenic potential of amphotericin B in somatic cells of Drosophila melanogaster.
Drug and chemical toxicology - 1 Jan 2018
Saturnino Rosiane Soares, Machado Nayane Moreira, Lopes Jeyson Cesary, Nepomuceno Júlio César
Abstract excerpt
Amphotericin B (AmB) is an antifungal antibiotic extracted from Streptomyces nodosus. Its fungicidal activity depends primarily on its binding to the sterol group that is present in fungal membranes. In view of the toxicity of this drug, the purpose of this study was to evaluate its mutagenic, carcinogenic, and recombinogenic activity, based on the wing somatic mutation and recombination test (SMART) and the...
Topics
- Amphotericin B
- Animals
- Animals, Genetically Modified
- Antifungal Agents
- Cell Transformation, Neoplastic
- Cytochrome P-450 Enzyme System
- Dose-Response Relationship, Drug
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation, Neoplastic
- Genotype
- Homologous Recombination