Article
Mutations induced by 1-nitrosopyrene and related compounds during DNA replication in human cells and induction of homologous recombination by these compounds.
Research report (Health Effects Institute) - 1 Mar 1993
Maher V M, Bhattacharyya N P, Mah M C, Boldt J, Yang J L, McCormick J J
Abstract excerpt
The transformation of normal human cells into cancer cells is a multistep process. Evidence suggests that a minimum of five independent steps (changes) are required for the development of certain kinds of human cancer, as well as for malignant transformation of human cells in culture. Mutations a...
Topics
- Animals
- Base Sequence
- Binding Sites
- Blotting, Southern
- Cell Line
- DNA
- DNA Replication
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Humans
- Mice
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Pyrenes
- Recombination, Genetic
- Sequence Deletion
- Transfection