Article
Cytochrome P450 CYP2D6 gene polymorphism and lung cancer susceptibility in Caucasians.
Pharmacogenetics - 1 Feb 1998
Legrand-Andréoletti M, Stücker I, Marez D, Galais P, Cosme J, Sabbagh N, Spire C, Cenée S, Lafitte J J, Beaune P, Broly F
Abstract excerpt
Many studies have been performed in an attempt to establish a link between the polymorphism of the cytochrome P450 CYP2D6 gene and the incidence of lung cancer. Nevertheless, whether or not this genetic polymorphism has a role in the development of the disease remains unclear. Recently, new advances in our knowledge of the CYP2D6 gene and its locus (CYP2D) have been achieved. In particular, CYP2D6 was found to be...
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