Article
Cytochrome P450 polymorphism--molecular, metabolic, and pharmacogenetic aspects. IV. Application of long polymerase chain reaction for identification of CYP2D6 gene duplication.
Acta poloniae pharmaceutica - 1 Jan 2000
Pułczyńska Agnieszka, Łukaszkiewicz Jacek, Wojnar Marcin, Tomaszewski Piotr, Kubiak-Tomaszewska Grazyna, Pachecka Jan
Abstract excerpt
In the human organism 58 cytochrome P450 (CYP) isoenzymes belonging to 18 families have been described. Isoenzyme CYP2D6 is an important human xenobiotic-metabolizing enzyme. CYP2D6 biotransforms a significant number of drugs, widely used in clinical practice, such as antidepressants, neuroleptics, antiarrhythmics, analgesics, antiemetics and anticancer agents. The occurrence of polymorphic variants of the enzyme...
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