CYP2D6 gene polymorphism in caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships.

doi:10.1016/s0959-8049(00)00185-4

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Article

CYP2D6 gene polymorphism in caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2000

Laforest L, Wikman H, Benhamou S, Saarikoski S T, Bouchardy C, Hirvonen A, Dayer P, Husgafvel-Pursiainen K

Abstract excerpt

Individual susceptibility to smoking-related cancers is proposed to partly depend on a genetically determined ability to metabolise tobacco carcinogens. We previously reported on the association between the activity of the xenobiotic-metabolising enzyme CYP2D6 and lung cancer risk in a hospital-based case-control study among French Caucasian smokers. Here we extended the study to address the effect of four...

Topics

Adult
Aged
Cytochrome P-450 CYP2D6
Female
Genetic Predisposition to Disease
Genotype
Humans
Lung Neoplasms
Male
Middle Aged
Odds Ratio
Phenotype
Polymorphism, Genetic
Risk Factors
Smoking

Source

Open in PubMed

Identifiers

PMID: 10974631
DOI: 10.1016/s0959-8049(00)00185-4

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