Article
Statistical considerations for genome-wide scans: design and application of a novel software package POLYMORPHISM.
Human heredity - 1 Jan 2001
Niu T, Struk B, Lindpaintner K
Abstract excerpt
OBJECTIVE: Given the cost and complexity of genome-wide scans, optimization of study design is of critical importance. Available algorithms only partially satisfy this need. We designed a software package called 'POLYMORPHISM' to meet these needs. METHODS: The program is designed to calculate linkage parameters for both 'single-point' and 'two-point' settings that are applicable also to incompletely informative...
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