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Article

Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysis.

BMC genetics - 30 Dec 2005

Xing Chao, Schumacher Fredrick R, Xing Guan, Lu Qing, Wang Tao, Elston Robert C

Abstract excerpt

There is growing evidence that a map of dense single-nucleotide polymorphisms (SNPs) can outperform a map of sparse microsatellites for linkage analysis. There is also argument as to whether a clustered SNP map can outperform an evenly spaced SNP map. Using Genetic Analysis Workshop 14 simulated data, we compared for linkage analysis microsatellites, SNPs, and composite markers derived from SNPs. We encoded the...

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PMID: 16451638
DOI: 10.1186/1471-2156-6-S1-S29
PMCID: PMC1866757

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