Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SNP-based linkage analysis in extended pedigrees: comparison between two alternative approaches.

Human heredity - 1 Jan 2014

Saint-Pierre Aude, D'Elia Yuri, Ciullo Marina, Pramstaller Peter P, Pattaro Cristian

Abstract excerpt

BACKGROUND: Linkage analysis on extended pedigrees is often challenged by the high computational demand of exact identity-by-descent (IBD) matrix reconstruction. When such an analysis becomes not feasible, two alternative solutions are contrasted: a full pedigree analysis based on approximate IBD estimation versus a pedigree splitting followed by exact IBD estimation. A multiple splitting (MS) approach, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Computer Simulation
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Lod Score

Share to Models, Genetic

Share to Pedigree

Share to Quantitative Trait Loci

Source

Identifiers

PMID: 24969533
DOI: 10.1159/000360623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SNP-based linkage analysis in extended pedigrees: comparison between two alternative approaches.PMID 24969533Read ↗

Efficient multipoint linkage analysis through reduction of inheritance space.Semantic proximity Read ↗

Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components.Semantic proximity Read ↗

Handling linkage disequilibrium in qualitative trait linkage analysis using dense SNPs: a two-step strategy.Semantic proximity Read ↗

Single-marker family-based association analysis conditional on parental information.Semantic proximity Read ↗

The role of pedigree information in combined linkage disequilibrium and linkage mapping of quantitative trait loci in a general complex pedigree.Semantic proximity Read ↗

Single Marker Family-Based Association Analysis Conditional on Parental Information.Semantic proximity Read ↗

PBAP: a pipeline for file processing and quality control of pedigree data with dense genetic markers.Semantic proximity Read ↗

Identifying the phenotypic effect of rare variants by including between-pedigree coancestry in variance components linkage analysisSemantic proximity Read ↗

Linkage analysis without defined pedigrees.Semantic proximity Read ↗

Grouping of genomic markers in populations with family structure.Semantic proximity Read ↗

Summary of Group 8: Development and extension of linkage methods.Semantic proximity Read ↗

The affected-pedigree-member method: power to detect linkage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.