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Article

Handling linkage disequilibrium in qualitative trait linkage analysis using dense SNPs: a two-step strategy.

BMC genetics - 10 Aug 2009

Cho Kelly, Dupuis Josée

Abstract excerpt

BACKGROUND: In affected sibling pair linkage analysis, the presence of linkage disequilibrium (LD) has been shown to lead to overestimation of the number of alleles shared identity-by-descent (IBD) among sibling pairs when parents are ungenotyped. This inflation results in spurious evidence for linkage even when the markers and the disease locus are not linked. In our study, we first theoretically evaluate how...

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PMID: 19664279
DOI: 10.1186/1471-2156-10-44
PMCID: PMC2731784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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