Handling linkage disequilibrium in qualitative trait linkage analysis using dense SNPs: a two-step strategy.

doi:10.1186/1471-2156-10-44

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Article

Handling linkage disequilibrium in qualitative trait linkage analysis using dense SNPs: a two-step strategy.

BMC genetics - 10 Aug 2009

Cho Kelly, Dupuis Josée

Abstract excerpt

BACKGROUND: In affected sibling pair linkage analysis, the presence of linkage disequilibrium (LD) has been shown to lead to overestimation of the number of alleles shared identity-by-descent (IBD) among sibling pairs when parents are ungenotyped. This inflation results in spurious evidence for l...

Topics

Algorithms
Chromosome Mapping
Computer Simulation
Genetic Markers
Linkage Disequilibrium
Lod Score
Models, Genetic
Polymorphism, Single Nucleotide
Quantitative Trait Loci

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