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Article

Program update and novel use of the DESPAIR program to design a genome-wide linkage study using relative pairs.

Human heredity - 1 Jan 2010

Ochs-Balcom Heather M, Guo Xiuqing, Yonebayashi Takashi, Wiesner Georgia, Elston Robert C

Abstract excerpt

DESPAIR (DESign for PAIRs) is a computer program useful for designing a two-stage linkage study using relative pairs for a dichotomous phenotype. It determines the optimal two-stage study design - i.e., for specified power and significance level, how many pairs of relatives should be studied, how many equally spaced markers should be used initially, and what criterion should be used to specify the markers around...

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Identifiers

PMID: 19797908
DOI: 10.1159/000243153
PMCID: PMC2880734

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Source receipt: pubmed, retrieved 7 Sept 2026.

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