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Article

Guidelines for genotyping in genomewide linkage studies: single-nucleotide-polymorphism maps versus microsatellite maps.

American journal of human genetics - 1 Oct 2004

Evans David M, Cardon Lon R

Abstract excerpt

Genomewide linkage scans have traditionally employed panels of microsatellite markers spaced at intervals of approximately 10 cM across the genome. However, there is a growing realization that a map of closely spaced single-nucleotide polymorphisms (SNPs) may offer equal or superior power to detect linkage, compared with low-density microsatellite maps. We performed a series of simulations to calculate the...

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PMID: 15311375
DOI: 10.1086/424696
PMCID: PMC1182056

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