Article
Guidelines for genotyping in genomewide linkage studies: single-nucleotide-polymorphism maps versus microsatellite maps.
American journal of human genetics - 1 Oct 2004
Evans David M, Cardon Lon R
Abstract excerpt
Genomewide linkage scans have traditionally employed panels of microsatellite markers spaced at intervals of approximately 10 cM across the genome. However, there is a growing realization that a map of closely spaced single-nucleotide polymorphisms (SNPs) may offer equal or superior power to detect linkage, compared with low-density microsatellite maps. We performed a series of simulations to calculate the...
Topics
- Chromosome Mapping
- Computer Simulation
- Genetic Markers
- Genetics, Medical
- Genome, Human
- Genotype
- Humans
- Microsatellite Repeats
- Pedigree
- Polymorphism, Single Nucleotide
- Siblings