Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ROSA26 LacZ-neo(R) insertion confers resistance to mammary tumors in Apc(Min/+) mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2001

Kohlhepp R L, Hegge L F, Moser A R

Abstract excerpt

B6.129S7-Gtrosa26 (ROSA26) mice carry a LacZ-neo(R) insertion on Chromosome (Chr) 6, made by promoter trapping with AB1 129 ES cells. Female C57BL/6J Apc(Min/+) (B6 Min/+) mice are very susceptible to the induction of mammary tumors after treatment with ethylnitrosourea (ENU). However, ENU-treated B6 mice carrying both Apc(Min) and ROSA26 are resistant to mammary tumor formation. Thus, ROSA26 mice carry a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Congenic
Share to Chromosomes
Share to Ethylnitrosourea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, APC

Share to Incidence

Share to Lac Operon

Share to Mammary Neoplasms, Experimental

Share to RNA, Untranslated

Source

Identifiers

PMID: 11471054
DOI: 10.1007/s003350020042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ROSA26 LacZ-neo(R) insertion confers resistance to mammary tumors in Apc(Min/+) mice.PMID 11471054Read ↗

ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development.Semantic proximity Read ↗

Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice.Semantic proximity Read ↗

Identification of novel modifier loci of Apc Min affecting mammary tumor development.Semantic proximity Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.Semantic proximity Read ↗

A strategy to identify dominant point mutant modifiers of a quantitative trait.Semantic proximity Read ↗

The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus.Semantic proximity Read ↗

Fine mapping and characterization of candidate lung tumor resistance genes for the Par2 locus on mouse chromosome 18.Semantic proximity Read ↗

Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis.Semantic proximity Read ↗

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.Semantic proximity Read ↗

Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.Semantic proximity Read ↗

Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.