Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A strategy to identify dominant point mutant modifiers of a quantitative trait.

G3 (Bethesda, Md.) - 17 Apr 2014

Dove William F, Shedlovsky Alexandra, Clipson Linda, Amos-Landgraf James M, Halberg Richard B, Krentz Kathleen J, Boehm Frederick J, Newton Michael A, Adams David J, Keane Thomas M

Abstract excerpt

A central goal in the analysis of complex traits is to identify genes that modify a phenotype. Modifiers of a cancer phenotype may act either intrinsically or extrinsically on the salient cell lineage. Germline point mutagenesis by ethylnitrosourea can provide alleles for a gene of interest that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breeding
Share to Crosses, Genetic
Share to Genes, APC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Genome

Share to Life Expectancy

Share to Point Mutation

Share to Quantitative Trait, Heritable

Source

Open in PubMed Open full text

Identifiers

PMID: 24747760
DOI: 10.1534/g3.114.010595
PMCID: PMC4065254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24747760-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A strategy to identify dominant point mutant modifiers of a quantitative trait.PMID 24747760Read ↗

Real-time resolution of point mutations that cause phenovariance in mice.Semantic proximity Read ↗

Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.Semantic proximity Read ↗

Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.Semantic proximity Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

Bulk segregation mapping of mutations in closely related strains of mice.Semantic proximity Read ↗

A targeted screen to detect recessive mutations that have quantitative effects.Semantic proximity Read ↗

Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice.Semantic proximity Read ↗

Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens.Semantic proximity Read ↗

The ROSA26 LacZ-neo(R) insertion confers resistance to mammary tumors in Apc(Min/+) mice.Semantic proximity Read ↗

Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis.Semantic proximity Read ↗

Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc (Min/+) mutation.Semantic proximity Read ↗

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: a fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.