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Article

Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice.

Cancer research - 15 Apr 2001

Moser A R, Hegge L F, Cardiff R D

Abstract excerpt

Treatment of female C57BL/6J (B6) mice carrying the mutant Min allele of the adenomatous polyposis coli (Apc) gene with ethylnitrosourea (ENU) results in approximately 90% of mice developing an average of three mammary tumors within 65 days. As a first step in the identification of loci modifying susceptibility to ENU-induced mammary tumors and hyperplasias, we have tested ENU-treated Apc(Min)/+ (Min/+) mice on...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mice, Inbred C57BL

Source

Identifiers

PMID: 11309311

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice.PMID 11309311Read ↗

Somatic mutational mechanisms involved in intestinal tumor formation in Min mice.Semantic proximity Read ↗

Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.Semantic proximity Read ↗

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.Semantic proximity Read ↗

Identification of novel modifier loci of Apc Min affecting mammary tumor development.Semantic proximity Read ↗

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.Semantic proximity Read ↗

The ROSA26 LacZ-neo(R) insertion confers resistance to mammary tumors in Apc(Min/+) mice.Semantic proximity Read ↗

ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development.Semantic proximity Read ↗

Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis.Semantic proximity Read ↗

The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus.Semantic proximity Read ↗

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.Semantic proximity Read ↗

Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice.Semantic proximity Read ↗

Opposite effects of modifiers of the ApcMin mutation in intestine and mammary gland.Semantic proximity Read ↗

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