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Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile

1 Jul 2001

Abstract excerpt

Toxigenic strains of Clostridium difficile produce two large bacterial toxins called toxins A (TcdA) and B (TcdB). tcdA and tcdB genes are located on the pathogenicity locus of C. difficile, a unique characteristic of toxigenic strains of this species. Intergenic to the two toxin genes is tcdE, a small 501-bp open reading frame of unknown function. Expression of the tcdE gene in Escherichia coli caused bacterial...

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PMID: 11444771
DOI: 10.1099/0022-1317-50-7-613

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Related research

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Research trail→

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Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficilePMID 11444771Read ↗

Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficileSemantic proximity Read ↗

Observations on the Role of TcdE Isoforms in Clostridium difficile Toxin Secretion.Semantic proximity Read ↗

The TcdE holin drives toxin secretion and virulence in <i>Clostridioides difficile</i>Semantic proximity Read ↗

A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficileSemantic proximity Read ↗

Release of TcdA and TcdB from Clostridium difficile cdi 630 is not affected by functional inactivation of the tcdE geneSemantic proximity Read ↗

Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal EffectsSemantic proximity Read ↗

Clostridium difficile: New Insights into the Evolution of the Pathogenicity LocusSemantic proximity Read ↗

The Complexity and Diversity of the Pathogenicity Locus in Clostridium difficile Clade 5Semantic proximity Read ↗

Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolutionSemantic proximity Read ↗

CdtR Regulates TcdA and TcdB Production in Clostridium difficileSemantic proximity Read ↗

Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B.Semantic proximity Read ↗

Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elementsSemantic proximity Read ↗

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