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Article

Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B.

Communications biology - 3 Jul 2020

Shen Enhui, Zhu Kangli, Li Danyang, Pan Zhenrui, Luo Yun, Bian Qiao, He Liuqing, Song Xiaojun, Zhen Ying, Jin Dazhi, Tao Liang

Abstract excerpt

Clostridioides difficile toxins (TcdA and TcdB) are major exotoxins responsible for C. difficile infection (CDI) associated diseases. The previously reported TcdB variants showed distinct biological features, immunoactivities, and potential pathogenicity in disease progression. Here, we performed global comparisons of amino acid sequences of both TcdA and TcdB from 3,269 C. difficile genomes and clustered them...

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Identifiers

PMID: 32620855
DOI: 10.1038/s42003-020-1078-y
PMCID: PMC7335066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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