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Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolution

1 Oct 2020

Abstract excerpt

Clostridioides difficile is a common cause of nosocomial diarrhoea. Toxins TcdA and TcdB are considered to be the main virulence factors and are encoded by the PaLoc region, while the binary toxin encoded in the CdtLoc region also contributes to pathogenicity. Variant toxinotypes reflect the genetic diversity of a key toxin-encoding 19 kb genetic element (the PaLoc). Here, we present analysis of a comprehensive...

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PMID: 33030421
DOI: 10.1099/mgen.0.000449

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