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Article

Observations on the Role of TcdE Isoforms in Clostridium difficile Toxin Secretion.

Journal of bacteriology - 1 Aug 2015

Govind Revathi, Fitzwater Leah, Nichols Rebekah

Abstract excerpt

UNLABELLED: Clostridium difficile is a major nosocomial pathogen and the principal causative agent of antibiotic-associated diarrhea. The toxigenic C. difficile strains that cause disease secrete virulence factors, toxin A and toxin B, that cause colonic injury and inflammation. C. difficile toxins have no export signature and are secreted by an unusual mechanism that involves TcdE, a holin-like protein. We...

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Source

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Identifiers

PMID: 26013487
DOI: 10.1128/JB.00224-15
PMCID: PMC4518823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Observations on the Role of TcdE Isoforms in Clostridium difficile Toxin Secretion.PMID 26013487Read ↗

The TcdE holin drives toxin secretion and virulence in <i>Clostridioides difficile</i>Semantic proximity Read ↗

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