Article

The TcdE holin drives toxin secretion and virulence in <i>Clostridioides difficile</i>

2023-09-16

Abstract excerpt

Clostridioides difficile is the leading cause of healthcare associated infections. The Pathogenicity Locus (PaLoc) toxins TcdA and TcdB promote host disease. These toxins lack canonical N-terminal signal sequences for translocation across the bacterial membrane, suggesting alternate mechanisms of release, which have included targeted secretion and passive release from cell lysis. While the holin TcdE has been impl...

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Literature Corpus work: a41cb0d3-6743-5681-a91a-7e2b73e8f316
DOI: 10.1101/2023.09.16.558055

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