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Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus

8 Oct 2015

Abstract excerpt

The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tcdE). To date, the PaLoc has always been found in the same location and is replaced in non-toxigenic strains by a highly conserved 75/115 bp...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26446480
DOI: 10.1038/srep15023

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