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Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects

3 May 2016

Abstract excerpt

Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly mediated by two exotoxins: toxin A (TcdA) and toxin B (TcdB). These toxins primarily disrupt the cytoskeletal structure and the tight junctions of target cells causing cell rounding and ultimately cell death. Detectable C. difficile...

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PMID: 27153087
DOI: 10.3390/toxins8050134

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