Article

A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficile

2025-09-22

Abstract excerpt

Clostridioides difficile infection is associated with the production of two large toxins, TcdA and TcdB. The toxins are encoded in a pathogenicity locus along with a phage-like holin protein, TcdE, the remnants of a phage endolysin, TcdL, and a positive transcriptional regulator, TcdR. Previous studies investigating the mechanism of toxin secretion from the bacterium have yielded disparate results as to whether th...

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Literature Corpus work: 4e8ae46b-8682-549c-b6d0-014e2c6d3121
DOI: 10.1101/2025.09.22.677799

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