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The Complexity and Diversity of the Pathogenicity Locus in Clostridium difficile Clade 5

9 Nov 2014

Abstract excerpt

The symptoms of Clostridium difficile infection are caused by two closely related toxins, TcdA and TcdB, which are encoded by the 19.6 kb Pathogenicity Locus (PaLoc). The PaLoc is variably present among strains, and in this respect it resembles a mobile genetic element. The C. difficile population structure consists mainly of five phylogenetic clades designated 1-5. Certain genotypes of clade 5 are associated...

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PMID: 25381663
DOI: 10.1093/gbe/evu248

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