Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile

18 Oct 2018

Abstract excerpt

The pathogenicity locus (PaLoc) of Clostridioides difficile usually comprises five genes (tcdR, tcdB, tcdE, tcdA, tcdC). While the proteins TcdA and TcdB represent the main toxins of this pathogen, TcdR and TcdC are involved in the regulation of their production. TcdE is a holin family protein, members of which are usually involved in the transport of cell wall-degrading enzymes (endolysins) for phage-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages and microbial interactions
Share to Clostridium difficile and Clostridium perfringens research
Share to Toxin Mechanisms and Immunotoxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30405545
DOI: 10.3389/fmicb.2018.02446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficilePMID 30405545Read ↗

Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficileSemantic proximity Read ↗

Observations on the Role of TcdE Isoforms in Clostridium difficile Toxin Secretion.Semantic proximity Read ↗

A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficileSemantic proximity Read ↗

The TcdE holin drives toxin secretion and virulence in <i>Clostridioides difficile</i>Semantic proximity Read ↗

Clostridium difficile: New Insights into the Evolution of the Pathogenicity LocusSemantic proximity Read ↗

Release of TcdA and TcdB from Clostridium difficile cdi 630 is not affected by functional inactivation of the tcdE geneSemantic proximity Read ↗

The Complexity and Diversity of the Pathogenicity Locus in Clostridium difficile Clade 5Semantic proximity Read ↗

CdtR Regulates TcdA and TcdB Production in Clostridium difficileSemantic proximity Read ↗

Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolutionSemantic proximity Read ↗

Clostridium difficile phages: still difficult?Semantic proximity Read ↗

Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates.Semantic proximity Read ↗

Bacteriophage endolysins as a potential weapon to combat Clostridioides difficile infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.