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CdtR Regulates TcdA and TcdB Production in Clostridium difficile

14 Jul 2016

Abstract excerpt

Clostridium difficile is a global health burden and the leading cause of antibiotic-associated diarrhoea worldwide, causing severe gastrointestinal disease and death. Three well characterised toxins are encoded by this bacterium in two genetic loci, specifically, TcdB (toxin B) and TcdA (toxin A) in the Pathogenicity Locus (PaLoc) and binary toxin (CDT) in the genomically distinct CDT locus (CdtLoc). Toxin...

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PMID: 27414650
DOI: 10.1371/journal.ppat.1005758

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