Article
Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on Chromosome 1.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2002
Phelan Shelley A, Beier David R, Higgins David C, Paigen Beverly
Abstract excerpt
Previously, we demonstrated that Ath1 is a quantitative trait locus for aortic fatty streak formation, located on Chromosome (chr) 1, with susceptibility in C57BL/6J mice and resistance in C3H/HeJ and BALB/cJ mice fed an atherogenic diet. In this study, we find an atherosclerosis susceptibility locus in the same region of Chr 1 by constructing two congenic strains with the resistance phenotype transferred from...
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