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Article

The mouse atherosclerosis locus at chromosome 10 (Ath11) acts early in lesion formation with subcongenic strains delineating 2 narrowed regions.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2010

Wolfrum Susanne, Rodríguez José M, Tan Marietta, Chen Kwan Y, Teupser Daniel, Breslow Jan L

Abstract excerpt

OBJECTIVE: Ath11, an atherosclerosis susceptibility locus on proximal chromosome 10 (0 to 21 cM) revealed in a cross between apolipoprotein E deficient C57BL/6 (B6) and FVB mice, was recently confirmed in congenic mice. The objectives of this study were to assess how Ath11 affects lesion development and morphology, to determine aortic gene expression in congenics, and to narrow the congenic interval. METHODS AND...

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Identifiers

PMID: 20466976
DOI: 10.1161/ATVBAHA.110.205757
PMCID: PMC2917113

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The mouse atherosclerosis locus at chromosome 10 (Ath11) acts early in lesion formation with subcongenic strains delineating 2 narrowed regions.PMID 20466976Read ↗

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