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Article

TGIF2 Interacts with Histone Deacetylase 1 and Represses Transcription

1 Aug 2001

Abstract excerpt

TG-interacting factor (TGIF) is a transcriptional repressor, which represses transcription by binding directly to DNA or interacts with transforming growth factor beta (TGF beta)-activated Smads, thereby repressing TGF beta-responsive gene expression. Mutation of TGIF in humans causes holoprosencephaly, a severe genetic disorder affecting craniofacial development. Searching human expressed sequence tag data bases...

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PMID: 11427533
DOI: 10.1074/jbc.m103377200

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TGIF2 Interacts with Histone Deacetylase 1 and Represses TranscriptionPMID 11427533Read ↗

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A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly.Semantic proximity Read ↗

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Transforming growth‐interacting factor (<i>TGIF</i>) regulates proliferation and differentiation of human myeloid leukemia cellsSemantic proximity Read ↗

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