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Transforming growth‐interacting factor (<i>TGIF</i>) regulates proliferation and differentiation of human myeloid leukemia cells

29 Jul 2009

Abstract excerpt

Transforming growth-interacting factor (TGIF) is a homeobox transcriptional repressor that has been implicated in holoprosencephaly and various types of cancer. TGIF is expressed in hematopoietic stem cells and modulates TGF-beta and retinoic acid (RA) signaling, both of which play an important role in hematopoiesis. We recently reported that TGIF's levels correlate inversely with survival in patients with acute...

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PMID: 19699159
DOI: 10.1016/j.molonc.2009.07.004

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