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Article

Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.

American journal of medical genetics. Part C, Seminars in medical genetics - 1 Jun 2018

Wotton David, Taniguchi Kenichiro

Abstract excerpt

Holoprosencephaly (HPE) is a frequent human forebrain developmental disorder with both genetic and environmental causes. Multiple loci have been associated with HPE in humans, and potential causative genes at 14 of these loci have been identified. Although TGIF1 (originally TGIF, for Thymine Guanine-Interacting Factor) is among the most frequently screened genes in HPE patients, an understanding of how mutations...

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Source

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Identifiers

PMID: 29749689
DOI: 10.1002/ajmg.c.31612
PMCID: PMC6125192

Genes

TGIF1
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.PMID 29749689Read ↗

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