Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.

doi:10.1038/s41598-018-20242-2

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Article

Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.

Scientific reports - 1 Feb 2018

Ishiguro Akira, Hatayama Minoru, Otsuka Maky I, Aruga Jun

Abstract excerpt

One of the causal genes for holoprosencephaly (HPE) is ZIC2 (HPE5). It belongs to the zinc finger protein of the cerebellum (Zic) family of genes that share a C2H2-type zinc finger domain, similar to the GLI family of genes. In order to clarify the role of Zic2 in gene regulation, we searched for its direct target genes using chromatin immunoprecipitation (ChIP). We identified TGIF1 (HPE4), another...

Topics

Animals
Gene Expression Regulation
Holoprosencephaly
Homeodomain Proteins
Mice
Mice, Inbred ICR
Mice, Knockout
Mutation
Promoter Regions, Genetic
Prosencephalon
Repressor Proteins
Transcription Factors
Transcriptional Activation

Source

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Identifiers

PMID: 29391420
DOI: 10.1038/s41598-018-20242-2
PMCID: PMC5794963

Genes

TGIF1
ZIC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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