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Article

TGIF Inhibits Retinoid Signaling

20 Jan 2006

Abstract excerpt

TGIF (TG-interacting factor) represses transforming growth factor beta (TGF-beta)-activated gene expression and can repress transcription via a specific retinoid response element. Mutations in human TGIF are associated with holoprosencephaly, a severe defect of craniofacial development with both genetic and environmental causes. Both TGF-beta and retinoic acid signaling are implicated in craniofacial development....

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Identifiers

PMID: 16428452
DOI: 10.1128/mcb.26.3.990-1001.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TGIF Inhibits Retinoid SignalingPMID 16428452Read ↗

TGIF2 Interacts with Histone Deacetylase 1 and Represses TranscriptionSemantic proximity Read ↗

Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling.Semantic proximity Read ↗

Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.Semantic proximity Read ↗

Intragenic deletion of Tgif causes defectsin brain development.Semantic proximity Read ↗

The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF.Semantic proximity Read ↗

Expression pattern of TG-interacting factor 2 during mouse development.Semantic proximity Read ↗

Transforming growth‐interacting factor (<i>TGIF</i>) regulates proliferation and differentiation of human myeloid leukemia cellsSemantic proximity Read ↗

Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.Semantic proximity Read ↗

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.Semantic proximity Read ↗

Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.Semantic proximity Read ↗

Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.Semantic proximity Read ↗

Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism.Semantic proximity Read ↗

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