Article
A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2007
Ferrand Nathalie, Demange Christine, Prunier Céline, Seo Su Ryeon, Atfi Azeddine
Abstract excerpt
The homeodomain protein TGIF functions as a negative modulator for multiple classes of transcription factors. Loss of function mutations in a single copy of TGIF result in holoprosencephaly, a developmental anomaly leading to severe forebrain and craniofacial malformations. However, the mechanisms by which these mutations disrupt the functions of TGIF remain to be elucidated. Here we show that a holoprosencephaly...
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