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Article

The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF.

The Journal of biological chemistry - 15 Dec 2000

Melhuish T A, Wotton D

Abstract excerpt

The homeodomain protein TGIF represses transcription in part by recruiting histone deacetylases. TGIF binds directly to DNA to repress transcription or interacts with TGF-beta-activated Smads, thereby repressing genes normally activated by TGF-beta. Loss of function mutations in TGIF result in holoprosencephaly (HPE) in humans. One HPE mutation in TGIF results in a single amino acid substitution in a conserved...

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Identifiers

PMID: 10995736
DOI: 10.1074/jbc.C000416200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF.PMID 10995736Read ↗

TGIF2 Interacts with Histone Deacetylase 1 and Represses TranscriptionSemantic proximity Read ↗

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.Semantic proximity Read ↗

A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly.Semantic proximity Read ↗

Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.Semantic proximity Read ↗

Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.Semantic proximity Read ↗

Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.Semantic proximity Read ↗

Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.Semantic proximity Read ↗

Intragenic deletion of Tgif causes defectsin brain development.Semantic proximity Read ↗

Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling.Semantic proximity Read ↗

TGIF Inhibits Retinoid SignalingSemantic proximity Read ↗

Expression pattern of TG-interacting factor 2 during mouse development.Semantic proximity Read ↗

Mutations in holoprosencephaly.Semantic proximity Read ↗

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