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Article

Intragenic deletion of Tgif causes defectsin brain development.

Human molecular genetics - 15 Dec 2006

Kuang Chenzhong, Xiao Yan, Yang Ling, Chen Qian, Wang Zhenzhen, Conway Simon J, Chen Yan

Abstract excerpt

TG-interacting factor (TGIF) is a homeodomain-containing protein and functions as a transcriptional repressor within the TGF-beta and retinoic acid signaling pathways. Heterozygous mutations of TGIF have been found in patients with holoprosencephaly (HPE), which is the most common congenital brain malformation in humans. However, targeted null deletions of the entire Tgif gene in mice surprisingly revealed no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17082251
DOI: 10.1093/hmg/ddl427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intragenic deletion of Tgif causes defectsin brain development.PMID 17082251Read ↗

Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.Semantic proximity Read ↗

Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.Semantic proximity Read ↗

Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.Semantic proximity Read ↗

Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling.Semantic proximity Read ↗

Expression pattern of TG-interacting factor 2 during mouse development.Semantic proximity Read ↗

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.Semantic proximity Read ↗

Mutations in holoprosencephaly.Semantic proximity Read ↗

A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly.Semantic proximity Read ↗

Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.Semantic proximity Read ↗

TGIF Inhibits Retinoid SignalingSemantic proximity Read ↗

TGIF2 Interacts with Histone Deacetylase 1 and Represses TranscriptionSemantic proximity Read ↗

The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF.Semantic proximity Read ↗

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