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Article

Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence.

American journal of medical genetics - 8 Jan 2001

Franke P, Wang T, Nöthen M M, Knapp M, Neidt H, Albrecht S, Jahnes E, Propping P, Maier W

Abstract excerpt

In the present investigation we hypothesized the A118G (Asn40Asp) polymorphism of the mu-opioid receptor gene (OPRM1) as a particular vulnerability factor for heroin and alcohol dependence. Therefore, we tested this hypothesis in two independent large samples by two different methods: a case-control sample (comprising n = 287 heroin and n = 221 alcohol study subjects versus n = 365 nondependent controls) and a...

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Source

Identifiers

PMID: 11424981

Genes

OPRM1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence.PMID 11424981Read ↗

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Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis.Semantic proximity Read ↗

Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone.Semantic proximity Read ↗

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