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Article

Polymorphisms in the mu-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans.

Pharmacogenomics - 1 Oct 2007

van der Zwaluw Carmen S, van den Wildenberg Esther, Wiers Reinout W, Franke Barbara, Buitelaar Jan, Scholte Ron H J, Engels Rutger C M E

Abstract excerpt

Twin and adoption studies have shown that alcohol dependence contains a substantial genetic component. In attempts to identify the genetic factors involved, association studies have linked the opioid system to alcohol dependence, with a main focus on the OPRM1 gene encoding the mu-opioid receptor. Our aim was to conduct a systematic review of the literature on the associations between polymorphisms in OPRM1 and...

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Source

Identifiers

PMID: 17979515
DOI: 10.2217/14622416.8.10.1427

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the mu-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans.PMID 17979515Read ↗

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Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans.Semantic proximity Read ↗

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Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.Semantic proximity Read ↗

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