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Article

Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis.

Drug and alcohol dependence - 27 Jul 2006

Arias Albert, Feinn Richard, Kranzler Henry R

Abstract excerpt

INTRODUCTION: The mu-opioid receptor has been implicated in the pathogenesis of dependence on opioids, alcohol, nicotine, and cocaine. Studies examining the association of the mu-opioid receptor gene (genetic locus OPRM1) with substance dependence (SD) have focused on the Asn40Asp (A118G) single...

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Source

Identifiers

PMID: 16387451
DOI: 10.1016/j.drugalcdep.2005.11.024

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16387451-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis.PMID 16387451Read ↗

The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review.Semantic proximity Read ↗

A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation.Semantic proximity Read ↗

Nonreplication of association between ?-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependenceSemantic proximity Read ↗

Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence.Semantic proximity Read ↗

μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption.Semantic proximity Read ↗

Systematic review and meta-analysis of the moderating effect of rs1799971 in OPRM1, the mu-opioid receptor gene, on response to naltrexone treatment of alcohol use disorder.Semantic proximity Read ↗

Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis.Semantic proximity Read ↗

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No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample.Semantic proximity Read ↗

Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms.Semantic proximity Read ↗

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.Semantic proximity Read ↗

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