Article
Misexpression of noggin leads to septal defects in the outflow tract of the chick heart.
Developmental biology - 1 Jul 2001
Allen S P, Bogardi J P, Barlow A J, Mir S A, Qayyum S R, Verbeek F J, Anderson R H, Francis-West P H, Brown N A, Richardson M K
Abstract excerpt
BMP-2 and BMP-4 are known to be involved in the early events which specify the cardiac lineage. Their later patterns of expression in the developing mouse and chick heart, in the myocardium overlying the atrioventricular canal (AV) and outflow tract (OFT) cushions, also suggest that they may play a role in valvoseptal development. In this study, we have used a recombinant retrovirus expressing noggin to inhibit...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.