Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis.

Circulation research - 2 Feb 2007

Choi Murim, Stottmann Rolf W, Yang Yu-Ping, Meyers Erik N, Klingensmith John

Abstract excerpt

Bone morphogenetic proteins (BMPs) play many roles in mammalian cardiac development. Here we address the functions of Noggin, a dedicated BMP antagonist, in the developing mouse heart. In early cardiac tissues, the Noggin gene is mainly expressed in the myocardial cells of the outflow tract, atrioventricular canal, and future right ventricle. The major heart phenotypes of Noggin mutant embryos are thicker...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Endocardium

Share to Morphogenesis

Share to Myocardium

Share to Neural Crest

Source

Identifiers

PMID: 17218603
DOI: 10.1161/01.RES.0000257780.60484.6a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis.PMID 17218603Read ↗

Misexpression of noggin leads to septal defects in the outflow tract of the chick heart.Semantic proximity Read ↗

Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart.Semantic proximity Read ↗

Control of endocardial cushion and cardiac valve maturation by BMP signaling pathways.Semantic proximity Read ↗

Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturitySemantic proximity Read ↗

The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation.Semantic proximity Read ↗

Role of bone morphogenetic proteins in cardiac differentiationSemantic proximity Read ↗

BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitorsSemantic proximity Read ↗

Myocardium and BMP signaling are required for endocardial differentiation.Semantic proximity Read ↗

BMP signaling is required for septation of the outflow tract of the mammalian heartSemantic proximity Read ↗

Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tractSemantic proximity Read ↗

Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest.Semantic proximity Read ↗

Dysregulated endocardial TGFβ signaling and mesenchymal transformation result in heart outflow tract septation failure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.