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Article

Dysregulated endocardial TGFβ signaling and mesenchymal transformation result in heart outflow tract septation failure.

Developmental biology - 1 Jan 2016

Ma Mancheong, Li Peng, Shen Hua, Estrada Kristine D, Xu Jian, Kumar S Ram, Sucov Henry M

Abstract excerpt

Heart outflow tract septation in mouse embryos carrying mutations in retinoic acid receptor genes fails with complete penetrance. In this mutant background, ectopic TGFβ signaling in the distal outflow tract is responsible for septation failure, but it was uncertain what tissue was responsive to ectopic TGFβ and why this response interfered with septation. By combining RAR gene mutation with tissue-specific Cre...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26522286
DOI: 10.1016/j.ydbio.2015.09.021
PMCID: PMC4742370

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