Article
Animal models of congenital defects in the ventriculoarterial connection of the heart.
Journal of molecular medicine (Berlin, Germany) - 1 Aug 1997
Ya J, Schilham M W, Clevers H, Moorman A F, Lamers W H
Abstract excerpt
The embryonic heart functions as a pump without one-way valves. To accomplish this, a long, slowly conducting myocardial structure, the outflow tract, functions as a sphincter at the arterial pole of the heart. During subsequent development tissue remodeling in the outflow tract and immigrating cells of the neural crest are responsible for connecting the right ventricle with the pulmonary trunk and the left...
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