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Article

The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation.

Circulation research - 12 Nov 2010

Zhang Jue, Chang Julia Y F, Huang Yanqing, Lin Xiang, Luo Yongde, Schwartz Robert J, Martin James F, Wang Fen

Abstract excerpt

RATIONALE: Heart valves develop from precursor structures called cardiac cushions, an endothelial-lined cardiac jelly that resides in the inner side of the heart tube. The cushions are then invaded by cells from different sources, undergo a series of complicated and poorly understood remodeling processes, and give rise to valves. Disruption of the fibroblast growth factor (FGF) signaling axis impairs...

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Source

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Identifiers

PMID: 20847311
DOI: 10.1161/CIRCRESAHA.110.225318
PMCID: PMC3052773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation.PMID 20847311Read ↗

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