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Article

BMP signaling is required for septation of the outflow tract of the mammalian heart

16 Dec 2002

Abstract excerpt

Bone morphogenetic proteins (BMPs) constitute a family of approximately 20 growth factors involved in a tremendous variety of embryonic inductive processes. BMPs elicit dose-dependent effects on patterning during gastrulation and gradients of BMP activity are thought to be established through regulation of the relative concentrations of BMP receptors, ligands and antagonists. We tested whether later developmental...

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PMID: 12441304
DOI: 10.1242/dev.00181

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